Description

1β,11β,12α-Trihydroxypicras-3-Ene-2,16-Dione is a highly functionalized triterpenoid derivative belonging to the quassinoid family, known for its complex stereochemistry and bioactive potential. This compound matters as a valuable advanced synthetic intermediate and a reference standard for research into novel pharmacologically active molecules. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of fine chemicals seeking high-purity, structurally complex building blocks.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis and study of novel therapeutic agents, particularly in anticancer and anti-inflammatory drug discovery programs.
• Natural Product Chemistry: Used as a purified standard for the identification, quantification, and bioactivity profiling of quassinoids and related triterpenes in plant extracts and complex matrices.
• Medicinal Chemistry: Acts as a sophisticated scaffold for structure-activity relationship (SAR) studies, enabling the exploration of chemical modifications to optimize biological activity and pharmacokinetic properties.
• Biochemical Research: Employed in enzymatic and receptor-binding assays to investigate specific biological pathways and mechanisms of action.
• Fine Chemical Synthesis: Utilized as a high-value starting material or intermediate for the multi-step synthesis of complex organic molecules in custom synthesis projects.
• Analytical Reference Standard: Provides a certified material for method development and validation in analytical techniques such as HPLC, LC-MS, and NMR for quality control in related product streams.

Basic Information

Item	Detail
Product Name	1β,11β,12α-Trihydroxypicras-3-Ene-2,16-Dione
CAS No.	4668-74-0
Molecular Formula	C20H28O6
Molecular Weight	364.43 g/mol
Synonyms	Picras-3-ene-2,16-dione, 1,11,12-trihydroxy-, (1β,11β,12α)-; 1β,11β,12α-Trihydroxypicras-3-ene-2,16-dione; Quassinoid derivative; Nigakilactone D (related structural class); Triterpenoid derivative; Contact for details on additional trade names and aliases.
EINECS	Contact for details

Quality Control

Our 1β,11β,12α-Trihydroxypicras-3-Ene-2,16-Dione is produced under a strict quality management system to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which may affect stability and handling properties. For long-term storage, consider inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.