Description

Verrucarin J CAS NO 4643-58-7 is a macrocyclic trichothecene mycotoxin, a secondary metabolite produced by certain fungi. This compound is of significant interest in biochemical and pharmacological research due to its potent biological activity, particularly as a protein synthesis inhibitor. It serves as a critical reference standard and research chemical for scientists in toxicology, mycology, and drug discovery. Target users include academic institutions, pharmaceutical R&D laboratories, and biotechnology companies investigating natural products, toxin mechanisms, or developing novel therapeutic agents.

Application

• Biochemical Research: Used as a high-purity reference standard in studies of trichothecene mycotoxins, their biosynthesis, and metabolic pathways.
• Pharmacological Studies: Serves as a tool compound for investigating protein synthesis inhibition, cytotoxicity, and the mechanisms of action of macrocyclic trichothecenes.
• Toxicology & Safety Testing: Employed as an analytical standard in the development and validation of methods (e.g., HPLC, LC-MS) for detecting mycotoxins in food, feed, and environmental samples.
• Natural Product Chemistry: Acts as a model compound for the synthesis, structural modification, and structure-activity relationship (SAR) studies of complex fungal metabolites.
• Cell Biology & Immunology Research: Utilized in vitro to study its effects on cell proliferation, apoptosis, and immune response modulation.

Basic Information

Product Name	Verrucarin J
CAS No.	4643-58-7
Molecular Formula	C₂₇H₃₄O₉
Molecular Weight	502.56 g/mol
Synonyms	Verrucarin J; 12,13-Epoxytrichothec-9-ene-3,4,8,15-tetrol, 4,15-diacetate 8-(3-methyl-2-butenoate); Roridin L2; Trichothec-9-ene-3,4,8,15-tetrol, 12,13-epoxy-, 4,15-diacetate 8-(3-methyl-2-butenoate); 4,15-Diacetoxy-12,13-epoxytrichothec-9-en-3,8-diol 8-(3-methyl-2-butenoate); (3α,4β,8α)-12,13-Epoxytrichothec-9-ene-3,4,8,15-tetrol 4,15-Diacetate 8-(3-Methyl-2-butenoate)
EINECS	Contact for details

Quality Control

Our Verrucarin J is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and structural confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and relevant analytical data. We support research compliance by making traceable documentation readily available.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The product is light-sensitive; prolonged exposure to light should be avoided to maintain stability. Keep the container in a dry, cool, and well-ventilated area. For long-term storage, consider storing desiccated at lower temperatures (e.g., -20°C).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.