Description

Ophiobolin A is a potent, naturally occurring sesterterpenoid mycotoxin produced by various plant pathogenic fungi. This compound is of significant interest in biochemical and pharmacological research due to its unique mode of action as a non-competitive inhibitor of calmodulin and its ability to induce programmed cell death. It serves as a critical reference standard and research tool for scientists in phytopathology, chemical biology, and anticancer drug discovery, enabling the study of calcium signaling pathways and the development of novel therapeutic agents.

Application

• Phytopathological Research: Used as a reference toxin to study plant-fungal interactions, disease mechanisms, and host resistance against pathogens like *Bipolaris* and *Cochliobolus* species.
• Biochemical Probe: Serves as a selective, non-competitive inhibitor of calmodulin (CaM) to investigate calcium-mediated signaling pathways in eukaryotic cells.
• Anticancer Research: Investigated for its potent cytotoxic activity and ability to induce apoptosis and autophagy in various cancer cell lines, making it a lead compound for novel oncology therapeutics.
• Chemical Biology Studies: Employed to explore its effects on mitochondrial function, reactive oxygen species (ROS) generation, and other cellular processes.
• Reference Standard: Essential for the qualitative and quantitative analysis (e.g., by HPLC, LC-MS) of ophiobolins in environmental, agricultural, and biological samples.

Basic Information

Product Name	Ophiobolin A
CAS No.	4611-05-6
Molecular Formula	C25H34O5
Molecular Weight	414.53 g/mol
Synonyms	Ophiobolin A; 3,4,4a,5,6,7,9,10,11,11a-Decahydro-7-hydroxy-6,10-dimethyl-3-methylene-4a,11a-epoxycyclodeca[b]furan-9-yl 3-methyl-2-butenoate; Cochliobolin A; 6-Epicochliobolin A; (3S,4aS,6R,9S,11aS)-3-Ethenyl-7-hydroxy-6,10-dimethyl-4a,11a-epoxy-1,3,4,4a,5,6,9,10,11,11a-decahydrocyclodeca[b]furan-9-yl 3-methylbut-2-enoate
EINECS	Contact for details

Quality Control

Our Ophiobolin A is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot is characterized using advanced analytical techniques, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all relevant specifications is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent condensation. The container should be kept in a dry, well-ventilated area designated for research chemicals.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.