Description

1,2-Dipalmitoylphosphatidylglycerol (DPPG) is a synthetic, saturated phospholipid that serves as a critical functional excipient and model membrane component. Its primary value lies in its ability to form stable, anionic lipid bilayers, which is essential for advanced drug delivery systems and biophysical research. This high-purity compound is particularly needed by pharmaceutical R&D teams, formulation scientists, and academic researchers working on liposomal therapeutics, pulmonary surfactants, and biomimetic membrane studies.

Application

• Liposomal Drug Delivery: A key anionic lipid component for creating stable, long-circulating, or targeted liposomes for cancer therapy, vaccines, and gene delivery.
• Pulmonary Surfactant Mimetics: Used in research and development of synthetic lung surfactants for treating respiratory distress syndrome (RDS).
• Biomimetic Membrane Models: Essential for constructing defined anionic lipid bilayers in vesicles (liposomes) and supported lipid bilayers (SLBs) for biophysical and membrane protein studies.
• Pharmaceutical Excipient: Functions as a stabilizer and charge modifier in complex injectable and inhaled formulations.
• Diagnostic Reagent Development: Utilized in the formulation of lipid-based reagents for diagnostic assays and imaging contrast agents.
• Cosmetic Actives Carrier: Employed in high-end cosmetic formulations for the encapsulation and targeted delivery of active ingredients.

Basic Information

Product Name	1,2-Dipalmitoylphosphatidylglycerol
CAS No.	4537-77-3
Molecular Formula	C38H75O10P
Molecular Weight	722.97 g/mol
Synonyms	DPPG; 1,2-Dihexadecanoyl-sn-glycero-3-phospho-(1'-rac-glycerol); Dipalmitoylphosphatidylglycerol; Phosphatidylglycerol (16:0/16:0); PG(16:0/16:0); 1,2-Dipalmitoyl-sn-glycero-3-phosphoglycerol; L-α-Phosphatidylglycerol, dipalmitoyl; (R)-2,3-Bis(hexadecanoyloxy)propyl (2,3-dihydroxypropyl) phosphate
EINECS	Contact for details

Quality Control

Our 1,2-Dipalmitoylphosphatidylglycerol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical and research applications. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Phase Transition Temperature (Tm)	Approx. 41°C
Solubility	Soluble in chloroform, methanol; insoluble in water
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.