Description

1,2-Distearoylphosphatidylethanolamine is a high-purity, fully saturated phospholipid belonging to the phosphatidylethanolamine (PE) class. This compound serves as a critical building block in the formulation of advanced lipid-based delivery systems, offering superior stability due to its saturated fatty acid chains. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and nutraceutical industries developing liposomes, lipid nanoparticles (LNPs), and other bilayer structures for drug delivery, diagnostics, and cosmetic applications.

Application

• Liposome and Lipid Nanoparticle (LNP) Formulation: A key structural phospholipid for creating stable, non-PEGylated vesicles for mRNA, siRNA, and small molecule drug delivery.
• Membrane Biophysics Research: Used as a model membrane component to study lipid bilayer properties, phase behavior, and protein-lipid interactions.
• Cosmetic Actives Carrier: Employed in high-end cosmetic formulations to encapsulate and enhance the delivery of active ingredients.
• Diagnostic Reagent Preparation: Utilized in the development of diagnostic assays and imaging contrast agents.
• Biomimetic Coatings: Applied in surface modification to create biocompatible, cell-membrane mimicking interfaces for medical devices.
• Excipient for Solid Lipid Nanoparticles (SLNs): Acts as a stabilizer and matrix lipid in SLN formulations for improved bioavailability.

Basic Information

Product Name	1,2-Distearoylphosphatidylethanolamine
CAS No.	4537-76-2
Molecular Formula	C41H82NO8P
Molecular Weight	748.06 g/mol
Synonyms	DSPE; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine; Distearoylphosphatidylethanolamine; Phosphatidylethanolamine, 1,2-distearoyl-; PE(18:0/18:0); L-α-Phosphatidylethanolamine, distearoyl; N-(1,2-Distearoyl-sn-glycero-3-phospho)ethanolamine
EINECS	Contact for details

Quality Control

Our 1,2-Distearoylphosphatidylethanolamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications for critical applications. Certificates of Analysis (COA) with full traceability are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. This material is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residual Solvents	Meets ICH guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.