Description

(3R,8Aα)-2,3,4,7,8,8A-Hexahydro-4β-Hydroxy-8β-(Hydroxymethyl)-8α-Methyl-1H-3Aα,7α-Methanoazulene-3β,6-Dicarboxylic Acid is a high-purity, complex organic acid derivative with a unique methanoazulene core structure. This compound serves as a critical chiral intermediate and building block for advanced chemical synthesis, valued for its defined stereochemistry and functional groups. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and fine chemical sectors for the development of novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of new drug candidates, particularly in areas requiring complex, polycyclic frameworks.
• Fine Chemical Synthesis: Serves as a versatile building block for synthesizing complex natural product analogs, flavors, and fragrances.
• Organic Chemistry Research: Used in academic and industrial R&D for methodological studies in stereoselective synthesis and catalysis.
• Material Science Precursor: Potential starting material for the synthesis of specialized polymers or ligands with specific steric and electronic properties.
• Bioconjugate Chemistry: The carboxylic acid groups enable its use in creating peptide or protein conjugates for biochemical applications.

Basic Information

Item	Details
Product Name	(3R,8Aα)-2,3,4,7,8,8A-Hexahydro-4β-Hydroxy-8β-(Hydroxymethyl)-8α-Methyl-1H-3Aα,7α-Methanoazulene-3β,6-Dicarboxylic Acid
CAS No.	4448-95-7
Molecular Formula	C₁₇H₂₂O₆
Molecular Weight	322.35 g/mol
Synonyms	4β-Hydroxy-8β-(hydroxymethyl)-8α-methyl-1H-3aα,7α-methanoazulene-3β,6-dicarboxylic acid, 2,3,4,7,8,8a-Hexahydro-; 3β,6-Dicarboxy-4β-hydroxy-8β-hydroxymethyl-8α-methyl-1H-3aα,7α-methanoazulene; 8β-(Hydroxymethyl)-8α-methyl-4β-hydroxy-2,3,4,7,8,8a-hexahydro-1H-3aα,7α-methanoazulene-3β,6-dicarboxylic acid; NSC 163049; A derivative of Podocarpic Acid.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is analyzed to confirm identity, purity, and impurity profile using advanced analytical techniques. Certificates of Analysis (COA) are available upon request, detailing specifications such as assay, chiral purity, and residual solvents. We adhere to a cGMP-compliant quality management system to ensure traceability and consistency for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.