Description

Ho-Peg18-Oh is a high-purity, monodisperse polyethylene glycol (PEG) derivative featuring a hydroxyl group at each terminus. This bifunctional structure is critical for creating stable, hydrophilic linkers and spacers in advanced material science and bioconjugation. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and specialty chemical sectors who require precise molecular architecture for drug delivery systems, hydrogel formation, and surface modification.

Application

• Pharmaceutical Linker: Serves as a crucial spacer in antibody-drug conjugates (ADCs) and peptide therapeutics to improve solubility and pharmacokinetics.
• Biomaterial Synthesis: A key building block for creating biocompatible hydrogels, scaffolds for tissue engineering, and smart polymer matrices.
• Surface PEGylation: Used to modify nanoparticles, quantum dots, and diagnostic agents to enhance biocompatibility and reduce immunogenicity.
• Polymer Chemistry: Acts as a macroinitiator or monomer for synthesizing block copolymers with tailored properties.
• Cross-linking Agent: Employed in the formulation of cross-linked networks for controlled release applications and specialty coatings.
• Chemical Probe Development: Utilized to introduce PEG chains into fluorescent dyes, sensors, and other molecular probes to alter their physical properties.

Basic Information

Product Name	Ho-Peg18-Oh
CAS No.	4445-03-8
Molecular Formula	C₃₈H₇₈O₁₉
Molecular Weight	838.99 g/mol
Synonyms	1,1'-[1,18-Dihydroxy-3,6,9,12,15-pentaoxaoctadecane-1,18-diyl]bis(oxy)bis(2-ethoxyethane); α,ω-Dihydroxy PEG18; 3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54-Octadecaoxaheptapentacontane-1,57-diol; PEG 900 diol; Poly(ethylene glycol) diol (MW ~900); 18-Mer PEG diol; Octadecaethylene glycol
EINECS	Contact for details

Quality Control

Our Ho-Peg18-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent molecular weight distribution, meeting the stringent requirements for research and GMP-grade applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere (nitrogen or argon) to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white waxy solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Molecular Weight (GPC)	800 - 950 g/mol
Polydispersity Index (PDI)	≤ 1.05
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.