Description

n-Palmitoylsphingosine is a high-purity, synthetic ceramide analog, specifically the N-acyl derivative of sphingosine with a palmitoyl chain. This compound is a critical biochemical tool and a key intermediate in the study of sphingolipid metabolism and cell signaling pathways. It is essential for researchers and manufacturers in the pharmaceutical, cosmetic, and life science industries developing advanced lipid-based therapeutics and skincare formulations.

Application

• Biochemical Research: A fundamental standard and precursor for studying ceramide-mediated apoptosis, cell differentiation, and stress responses.
• Pharmaceutical Intermediates: Serves as a key building block in the synthesis of novel sphingolipid-based drugs targeting cancer, inflammatory diseases, and metabolic disorders.
• Cosmetic Science: Used in the development of high-performance skincare products to restore the skin barrier, improve hydration, and combat signs of aging.
• Lipidomics & Analytical Standards: Employed as a certified reference material (CRM) for the accurate quantification of ceramides in biological samples via LC-MS/MS.
• Cell Culture & Media Supplements: Incorporated into specialized media to investigate the role of sphingolipids in cellular processes under controlled conditions.
• Enzyme Substrate: Acts as a substrate for enzymes like ceramidases and sphingomyelin synthases in enzymatic activity assays.

Basic Information

Product Name	n-Palmitoylsphingosine
CAS No.	4201-58-5
Molecular Formula	C₃₄H₆₇NO₃
Molecular Weight	537.90 g/mol
Synonyms	N-(Hexadecanoyl)-sphingosine; D-erythro-Ceramide (d18:1/16:0); Ceramide 3; Palmitoyl-D-erythro-sphingosine; N-Palmitoyl-D-sphingosine; C16-Ceramide; (2S,3R,4E)-2-Hexadecanoylamino-4-octadecene-1,3-diol; N-Palmitoylsphingosine
EINECS	224-100-7

Quality Control

Every batch of our n-Palmitoylsphingosine is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with relevant industry standards for research and pharmaceutical intermediates. A detailed Certificate of Analysis (COA), providing purity, identity, and impurity profile data from techniques like HPLC, NMR, and MS, is supplied with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. Keep the material in a cool, dry, and well-ventilated area away from incompatible substances.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	95 - 105 °C
Loss on Drying	≤ 1.0 %
Heavy Metals	≤ 20 ppm
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.