Description

n-Methylnalorphine is a specialized pharmaceutical reference standard and research chemical of significant interest in neuropharmacology. Its primary value lies in its role as a potent opioid antagonist, used extensively in scientific studies to investigate receptor binding and analgesic pathways. This compound is essential for researchers and developers in the pharmaceutical, biotechnology, and academic sectors focused on central nervous system (CNS) drug discovery and neurochemical analysis.

Application

• Pharmacological Research: Critical tool for studying opioid receptor (mu, kappa, delta) interactions, antagonism, and signal transduction mechanisms.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of related pharmaceutical compounds.
• Neurochemical Studies: Employed in preclinical research to explore the modulation of pain perception and the physiological effects of opioid blockade.
• Drug Discovery & Development: Serves as a key intermediate or biological probe in the synthesis and screening of new analgesic or addiction treatment therapies.
• Forensic & Clinical Toxicology: Utilized as a calibrant or control in assays designed to detect and quantify opioid derivatives in biological samples.

Basic Information

Product Name	n-Methylnalorphine
CAS No.	4121-75-9
Molecular Formula	C₂₀H₂₅NO₄
Molecular Weight	343.42 g/mol
Synonyms	N-Methylnalorphine; 17-Methyl-7,8-didehydro-4,5α-epoxy-3,6α-dihydroxy-N-methylmorphinan-6-one; N-Methyl-N-allylnormorphine; N-Methylnalorphinium; N-Methylnalorfina; N-Methylnalorphin
EINECS	223-918-5

Quality Control

Our n-Methylnalorphine is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with relevant guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The material is light-sensitive and should be handled to minimize prolonged exposure.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.