Description

2-Hydroxy-3,3-Dimethylbutyric Acid is a specialized organic compound featuring a tertiary butyl group adjacent to a chiral hydroxyl-bearing carbon, making it a valuable chiral building block and intermediate. This structural motif is critical for synthesizing high-value compounds where precise stereochemistry and steric bulk are required. It is primarily sought after by the pharmaceutical, agrochemical, and fine chemical industries for applications in asymmetric synthesis and the development of active ingredients.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in statin drugs and other therapeutics requiring specific stereocenters.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where the bulky dimethylbutyric acid moiety can influence biological activity and stability.
• Fine Chemical & Catalyst Ligand Precursor: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and other high-precision chemical transformations.
• Flavor & Fragrance Industry: Potential intermediate for synthesizing esters and other compounds that contribute to complex flavor and aroma profiles.
• Polymer Modification: Can be incorporated as a functional monomer to introduce hydroxyl groups and steric hindrance into polymer chains, modifying physical properties.
• Research & Development: Essential compound in organic chemistry R&D for method development and exploring new synthetic routes to complex molecules.

Basic Information

Product Name	2-Hydroxy-3,3-Dimethylbutyric Acid
CAS No.	4026-20-4
Molecular Formula	C6H12O3
Molecular Weight	132.16 g/mol
Synonyms	3,3-Dimethyl-2-hydroxybutyric Acid; 2-Hydroxy-3,3-dimethylbutanoic Acid; α-Hydroxy-β,β-dimethylbutyric Acid; (R/S)-2-Hydroxy-3,3-dimethylbutyric Acid; DL-2-Hydroxy-3,3-dimethylbutyric Acid; Hydroxydimethylbutyric Acid; 4026-20-4
EINECS	223-700-4

Quality Control

Our 2-Hydroxy-3,3-Dimethylbutyric Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including assay, chiral purity, and impurity profiling, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing specific results are provided with every shipment. We can supply material compliant with various customer-specific requirements, including those for cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Store away from incompatible materials such as strong oxidizing agents, strong bases, and strong acids.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Contact for details
Melting Point	85 - 90 °C
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.