Description

(+)-Bicuculline CAS NO 485-49-4 is a potent and selective competitive antagonist of the GABAA receptor, a key ionotropic receptor in the mammalian central nervous system. This compound is an indispensable pharmacological tool for neuroscience research, enabling the study of inhibitory neurotransmission, synaptic plasticity, and neurological disorders. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on neuropharmacology and neurotoxicology.

Application

• Neuroscience Research: A fundamental tool for studying GABAergic inhibition, receptor physiology, and neuronal excitability in vitro and in vivo.
• Pharmacological Screening: Used as a reference standard in high-throughput assays to identify novel GABAA receptor modulators or antagonists.
• Neurotoxicology Studies: Employed to investigate the mechanisms of convulsant agents and to model seizure activity for anticonvulsant drug development.
• Electrophysiology: Critical for patch-clamp and other electrophysiological experiments to block GABA-induced chloride currents.
• Biochemical Assays: Used in receptor binding studies (e.g., competitive displacement assays) to characterize receptor subtypes and ligand affinities.
• Academic & Institutional Research: Supports fundamental research in universities and government labs exploring brain function and neurological disease pathways.

Basic Information

Product Name	(+)-Bicuculline
CAS No.	485-49-4
Molecular Formula	C20H17NO6
Molecular Weight	367.35 g/mol
Synonyms	(+)-Bicuculline; Bicuculline; (S)-(+)-Bicuculline; d-Bicuculline; NSC 22445; 6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one
EINECS	207-618-1

Quality Control

Our (+)-Bicuculline is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support research compliance with traceable documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed immediately after use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	+130° to +135° (c=1 in CHCl3)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.