Description

Colchiceine CAS NO 477-27-0 is a key alkaloid derivative and a primary metabolite of colchicine, known for its significant biological activity. This compound is of paramount importance in pharmaceutical research and development, serving as a crucial intermediate and reference standard. It is primarily utilized by research institutions, pharmaceutical manufacturers, and biotechnology companies engaged in anti-inflammatory drug discovery, gout treatment studies, and the investigation of tubulin polymerization inhibitors.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel colchicine analogs and other therapeutic agents.
• Reference Standard: Used for quality control, method development, and calibration in analytical laboratories (HPLC, LC-MS).
• Biochemical Research: Employed in studies of microtubule dynamics, cell cycle regulation, and anti-mitotic mechanisms.
• Anti-inflammatory & Anti-gout Research: Investigated for its potential therapeutic effects in models of inflammation and gout.
• Academic & R&D: A vital tool for universities and contract research organizations (CROs) exploring tropolone chemistry and its biological applications.

Basic Information

Product Name	Colchiceine
CAS No.	477-27-0
Molecular Formula	C₂₁H₂₃NO₆
Molecular Weight	385.41 g/mol
Synonyms	Colchiceine; 3-Demethylcolchicine; Deacetylcolchicine; N-Deacetyl-N-methylcolchicine; Colchiceïne; NSC 75744; 2,3,4,9-Tetrahydro-10-methoxy-1,2,3,4,5,6-hexahydrobenzo[a]heptalen-11(7H)-one, 5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-7-(methylamino)-, (7S)-
EINECS	207-517-7

Quality Control

Our Colchiceine is produced and tested under a rigorous quality management system. Each batch is analyzed to ensure high purity and consistency, with specifications aligned with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.