Description

Tolbutamide Sodium CAS NO 473-41-6 is the sodium salt form of the first-generation sulfonylurea drug, tolbutamide, known for its high purity and consistent performance. This compound is a critical intermediate and active pharmaceutical ingredient (API) in the development and manufacturing of antidiabetic medications. It is primarily required by pharmaceutical manufacturers, research institutions, and fine chemical suppliers engaged in metabolic disorder therapeutics and analytical standard preparation.

Application

• Pharmaceutical API: Core active ingredient in the formulation of oral hypoglycemic agents for Type 2 diabetes management.
• Research & Development: Used in biochemical and pharmacological studies to investigate insulin secretion mechanisms and sulfonylurea receptor activity.
• Reference Standard: Serves as a high-purity calibrant and standard in analytical laboratories for quality control (QC) and method validation using HPLC, LC-MS, or NMR.
• Intermediate Synthesis: Key starting material or precursor in the synthetic pathways for more complex sulfonylurea derivatives and related compounds.
• Veterinary Medicine: Potential application in the development of glycemic control treatments for companion animals.

Basic Information

Product Name	Tolbutamide Sodium
CAS No.	473-41-6
Molecular Formula	C12H17N2NaO3S
Molecular Weight	292.33 g/mol
Synonyms	1-Butyl-3-(p-tolylsulfonyl)urea sodium salt; Sodium tolbutamide; Orinase Sodium; N-[(Butylamino)carbonyl]-4-methylbenzenesulfonamide sodium salt; Tolbutamide Na; Arcosal; Rastinon Sodium; U-2043
EINECS	207-468-9

Quality Control

Our Tolbutamide Sodium is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with relevant standards. We support cGMP (current Good Manufacturing Practice) principles for API production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light); therefore, containers must be kept tightly sealed to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
pH (5% solution)	7.5 - 9.5

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.