Description

Cafestol is a natural diterpene ester, a key bioactive compound found in coffee beans. This high-purity material is valued for its significant role in pharmacological and nutritional research, particularly in studies related to cholesterol metabolism and inflammation. It is an essential reference standard and raw material for researchers and manufacturers in the nutraceutical, pharmaceutical, and food science industries seeking to develop or analyze coffee-derived products.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification, assay, and purity testing of coffee extracts and related products in QC/QA laboratories.
• Nutraceutical Research & Development: A critical ingredient for studying and formulating dietary supplements aimed at exploring lipid metabolism and anti-inflammatory effects.
• Analytical Chemistry: Serves as a primary standard for HPLC, LC-MS, and GC-MS methods to quantify cafestol and related diterpenes in complex matrices.
• Food & Beverage Science: Employed in research to understand the impact of brewing methods on the chemical composition and health profile of coffee.
• Biological Activity Studies: Utilized in *in vitro* and *in vivo* research to investigate its chemopreventive, hepatoprotective, and biological modulating properties.
• Cosmetic Ingredient Research: Investigated for potential topical applications due to its antioxidant and anti-inflammatory characteristics.

Basic Information

Product Name	Cafestol
CAS No.	469-83-0
Molecular Formula	C20H28O3
Molecular Weight	316.44 g/mol
Synonyms	Cafestol; (-)-Cafestol; NSC 169904; 13-Methyl-6,16-dioxapentacyclo[10.7.1.02,9.04,8.014,19]icosa-1(19),2,4(8),5,9,11,14,16-octaen-12-ol, 15,16-epoxy-3-methoxy-12,15-dimethyl-, (12R)-; Coffee diterpene; Kahweol related diterpene
EINECS	Contact for details

Quality Control

Our Cafestol is produced and handled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed immediately after use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0% (Typical 97-99%)
Loss on Drying	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.