Description

Isopetasin CAS NO 469-26-1 is a natural sesquiterpene lactone compound, a key bioactive constituent found in the butterbur plant (*Petasites hybridus*). This compound matters for its significant role in pharmaceutical research and development, particularly in the study of anti-inflammatory and smooth muscle relaxant pathways. It is primarily needed by research institutions, pharmaceutical companies, and nutraceutical manufacturers focused on developing therapeutic agents for conditions like migraines, allergies, and inflammation.

Application

• Pharmaceutical Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in drug development and herbal extract analysis.
• Bioactive Ingredient Research: Used in preclinical studies to investigate its pharmacological properties, including anti-inflammatory, antispasmodic, and anti-allergic effects.
• Natural Product Isolation & Synthesis: Acts as a target molecule for isolation protocols from natural sources or as a benchmark in synthetic chemistry routes.
• Herbal Extract Standardization: Employed to standardize butterbur (*Petasites*) extracts, ensuring consistent potency and efficacy in finished dietary supplements.
• Mechanistic Studies: Utilized in biochemical assays to elucidate its mechanism of action, particularly concerning calcium channel modulation and leukotriene inhibition.

Basic Information

Product Name	Isopetasin
CAS No.	469-26-1
Molecular Formula	C₁₇H₂₄O₅
Molecular Weight	308.37 g/mol
Synonyms	Isopetasin; (3aR,4S,6aR,9aS,9bR)-4-(Acetyloxy)-3a,4,5,6,6a,9,9a,9b-octahydro-3,6,9-trimethylenenaphtho[1,2-c]furan-8(3H)-one; Petasin isomer; NSC 169865; 8-Oxo-9,10-dehydro-7(11)-eremophilene-12,8-olide
EINECS	Contact for details

Quality Control

Our Isopetasin is produced and handled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity confirmation and identity verification by spectroscopic methods (IR, NMR). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive compound from degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.