Description

Piperazine, 1-(3,3,3-Trifluoropropyl)- (9Ci) CAS NO 399580-61-1 is a specialized fluorinated piperazine derivative, a high-value intermediate designed for advanced pharmaceutical and agrochemical synthesis. Its core value lies in the unique trifluoropropyl moiety, which imparts enhanced metabolic stability and lipophilicity to target molecules, a critical property in modern drug and crop protection agent design. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorine into complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology drug candidates.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the fluorine group enhances biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced materials with specific surface properties.
• Chemical Biology Probes: Useful for creating tagged molecules to study biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring fluorinated piperazine scaffolds.

Basic Information

Item	Details
Product Name	Piperazine, 1-(3,3,3-Trifluoropropyl)- (9Ci)
CAS No.	399580-61-1
Molecular Formula	C7H13F3N2
Molecular Weight	182.19 g/mol
Synonyms	1-(3,3,3-Trifluoropropyl)piperazine; N-(3,3,3-Trifluoropropyl)piperazine; 3,3,3-Trifluoropropyl-piperazine; Piperazine, 1-(3,3,3-trifluoropropyl)-; 399580-61-1; 1-(3,3,3-Trifluoropropyl)piperazine (9CI); 1-(3,3,3-Trifluoropropyl)piperazine (9Ci)
EINECS	Contact for details

Quality Control

Every batch of 1-(3,3,3-Trifluoropropyl)piperazine is produced and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and cGMP manufacturing. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting identity, purity (typically by GC/HPLC), and impurity profiles. Our quality commitment aligns with ICH guidelines and supports regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.