Description

Rosiglitazone D-Tartrate is the D-tartrate salt form of the thiazolidinedione-class antidiabetic agent, Rosiglitazone. This specific salt form is valued for its enhanced stability and defined crystalline properties, which are critical for precise formulation in pharmaceutical development. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in metabolic disorder research and the production of high-purity active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for quality control and analytical method validation in API manufacturing.
• Active Pharmaceutical Ingredient (API) Intermediate: A key starting material or intermediate in the synthesis of finished Rosiglitazone-based drug products.
• Biochemical Research: Used in in vitro and in vivo studies to investigate PPAR-γ (Peroxisome Proliferator-Activated Receptor gamma) agonist activity and insulin sensitization mechanisms.
• Metabolic Disorder Research: A critical tool for preclinical research targeting Type 2 diabetes, insulin resistance, and related metabolic syndromes.
• Formulation Development: Employed in the development and stability testing of solid dosage forms such as tablets.
• Analytical Testing: Used as a high-purity calibrant in HPLC, LC-MS, and other chromatographic assays for quantitative analysis.

Basic Information

Product Name	Rosiglitazone D-Tartrate
CAS No.	397263-60-4
Molecular Formula	C₁₈H₁₉N₃O₃S • C₄H₆O₆
Molecular Weight	573.58 g/mol
Synonyms	Rosiglitazone (S,S)-(+)-Tartrate; Rosiglitazone D-(-)-Tartrate; Rosiglitazone (+)-Tartrate; 5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione (2R,3R)-2,3-dihydroxybutanedioate (1:1); Avandia Tartrate; BRL 49653 D-Tartrate
EINECS	Contact for details

Quality Control

Our Rosiglitazone D-Tartrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for assay and purity, chiral purity determination, and residual solvent analysis, to ensure it meets stringent specifications for pharmaceutical use. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with relevant standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Chiral Purity (HPLC)	≥99.0% (D-Tartrate isomer)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity: ≤0.5%; Total impurities: ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.