Description

tert-Butyl 4-picolinoylpiperazine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core functionalized with picolinoyl and tert-butoxycarbonyl (Boc) protecting groups. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in the areas of kinase inhibitors and central nervous system (CNS) active compounds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, especially those targeting protein kinases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes.
• Protecting Group Strategy: The tert-butoxycarbonyl (Boc) group provides a base-labile protecting group for the piperazine nitrogen, enabling selective deprotection in multi-step syntheses.
• Ligand Synthesis: Serves as a precursor for creating complex ligands used in catalysis or as pharmacophores.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific molecule development.
• Academic Research: Used in university and institutional labs for exploratory synthetic chemistry and bioorganic research projects.

Basic Information

Product Name	tert-Butyl 4-Picolinoylpiperazine-1-Carboxylate
CAS No.	389628-28-8
Molecular Formula	C15H21N3O3
Molecular Weight	291.35 g/mol
Synonyms	1-Boc-4-(picolinoyl)piperazine; 1-(tert-Butoxycarbonyl)-4-(pyridine-2-carbonyl)piperazine; 4-Picolinoylpiperazine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(2-pyridylcarbonyl)piperazine-1-carboxylate; 1-Boc-4-(2-pyridylcarbonyl)piperazine; N-Boc-4-picolinoylpiperazine; Piperazine, 4-(2-pyridinylcarbonyl)-, 1-(1,1-dimethylethyl) ester; 389628-28-8
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-picolinoylpiperazine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.