Description

4-Amino-Piperidine-1,3-Dicarboxylic Acid 1-tert-Butyl Ester is a high-purity, protected amino acid derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in providing a versatile, stereochemically defined scaffold for constructing complex molecular architectures, particularly in pharmaceutical research. This compound is essential for medicinal chemists and process development scientists working on new active pharmaceutical ingredients (APIs), especially within therapeutic areas requiring sophisticated peptide-mimetics and constrained heterocycles.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Peptidomimetic Chemistry: Used to introduce constrained piperidine scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Chemical Biology & Proteomics: Employed in the development of activity-based probes and molecular tags for studying enzyme function.
• Asymmetric Synthesis: Serves as a starting material or auxiliary for constructing enantiomerically pure compounds in academic and industrial R&D.
• Agrochemical Research: Potential intermediate in the development of novel, high-performance crop protection agents with specific modes of action.
• Material Science: Can be utilized in the synthesis of specialized polymers and dendrimers with tailored functional properties.

Basic Information

Product Name	4-Amino-Piperidine-1,3-Dicarboxylic Acid 1-tert-Butyl Ester
CAS No.	388108-90-5
Molecular Formula	C11H20N2O4
Molecular Weight	244.29 g/mol
Synonyms	1-tert-Butyl 4-amino-1,3-piperidinedicarboxylate; 1-(tert-Butoxycarbonyl)-4-amino-3-piperidinecarboxylic Acid; 4-Amino-1-Boc-piperidine-3-carboxylic Acid; 4-Amino-3-carboxypiperidine-1-carboxylic Acid tert-Butyl Ester; tert-Butyl 4-amino-3-carboxypiperidine-1-carboxylate; Boc-4-Amino-piperidine-3-carboxylic Acid; 1-Boc-4-amino-piperidine-3-carboxylic Acid; 388108-90-5
EINECS	Contact for details

Quality Control

Our 4-Amino-Piperidine-1,3-Dicarboxylic Acid 1-tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D and scale-up. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.