Description

(3R,4R)-4-Aminopiperidine-1,3-Dicarboxylic Acid 1-tert-Butyl Ester 3-Ethyl Ester is a high-purity, stereochemically defined chiral piperidine derivative. This compound serves as a critical advanced pharmaceutical intermediate (API intermediate) and a versatile chiral building block for the synthesis of complex bioactive molecules. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams developing new therapeutic agents, particularly in areas requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially those targeting the central nervous system (CNS) and infectious diseases.
• Chiral Auxiliary/Synthon: Utilized in asymmetric synthesis to introduce the (3R,4R)-configured aminopiperidine moiety, a privileged scaffold in medicinal chemistry.
• Protease Inhibitor Research: Core structural element for the development of inhibitors for various protease enzymes.
• Chemical Biology & Probe Development: Used in the creation of molecular probes to study biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Sourced by CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.
• Academic Research: Employed in university and institutional labs for methodological development in organic synthesis and medicinal chemistry projects.

Basic Information

Product Name	(3R,4R)-4-Aminopiperidine-1,3-Dicarboxylic Acid 1-tert-Butyl Ester 3-Ethyl Ester
CAS No.	388108-34-7
Molecular Formula	C13H24N2O4
Molecular Weight	272.34 g/mol
Synonyms	(3R,4R)-1-(tert-Butoxycarbonyl)-4-amino-3-(ethoxycarbonyl)piperidine; (3R,4R)-4-Amino-1-N-Boc-piperidine-3-carboxylic acid ethyl ester; (3R,4R)-1-Boc-4-amino-3-ethoxycarbonylpiperidine; tert-Butyl (3R,4R)-4-amino-3-(ethoxycarbonyl)piperidine-1-carboxylate; (3R,4R)-4-Amino-3-ethoxycarbonylpiperidine-1-carboxylic acid tert-butyl ester; Boc-4-Amino-3-ethoxycarbonylpiperidine (3R,4R)-isomer; CAS 388108-34-7
EINECS	Contact for details

Quality Control

Our (3R,4R)-4-Aminopiperidine-1,3-Dicarboxylic Acid 1-tert-Butyl Ester 3-Ethyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chiral purity and chemical assay, NMR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (diastereomeric excess)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.