Description

1,5-Cyclohexadiene-1-Carbonyl Chloride, 2,6-Difluoro- (9Ci) is a specialized fluorinated organic building block characterized by a reactive acid chloride group on a diene scaffold. This compound matters as a high-value intermediate for constructing complex molecular architectures, particularly in advanced pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the fine chemical and life sciences industries for synthesizing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated drug candidates, including kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the fluorine atoms and reactive site can enhance biological activity and stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers with unique optical or electronic properties.
• Ligand and Catalyst Development: Employed in the synthesis of complex, fluorinated ligands for catalysis and molecular recognition applications.
• Chemical Biology Probes: Useful for creating fluorescent tags or affinity probes due to its reactive carbonyl chloride group, which can conjugate to amines and other nucleophiles.
• Academic & Contract Research: A valuable reagent for methodology development and exploratory organic synthesis in university and CRO laboratories.

Basic Information

Product Name	1,5-Cyclohexadiene-1-Carbonyl Chloride, 2,6-Difluoro- (9Ci)
CAS No.	387337-22-6
Molecular Formula	C7H5ClF2O
Molecular Weight	178.56 g/mol
Synonyms	2,6-Difluoro-1,5-cyclohexadiene-1-carbonyl chloride; 2,6-Difluorocyclohexa-1,5-diene-1-carbonyl chloride; 1,5-Cyclohexadiene-1-carbonyl chloride, 2,6-difluoro-; 387337-22-6; 2,6-Difluoro-1,5-cyclohexadiene-1-carboxylic acid chloride
EINECS	Contact for details

Quality Control

Our production of 1,5-Cyclohexadiene-1-Carbonyl Chloride, 2,6-Difluoro- (9Ci) adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We employ advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy to verify specifications. Certificates are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, oxidizers, and sources of moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.