Description

1,4-Piperazinedicarboxylic Acid, 2-(Hydroxymethyl)-, 1-(1,1-Dimethylethyl) 4-(Phenylmethyl) Ester, (2S)- is a high-purity, chiral piperazine derivative serving as a critical building block in advanced pharmaceutical synthesis. This compound matters because it provides a structurally complex and stereochemically defined scaffold essential for developing novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring high specificity. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new drugs, including protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Protease Inhibitor Development: Used in research and production of protease inhibitors for treating viral infections and other diseases.
• Kinase Inhibitor Scaffold: Serves as a core structural component in the design and synthesis of novel kinase inhibitors for oncology and inflammatory diseases.
• Peptidomimetic Chemistry: Employed in creating peptidomimetics, where its piperazine core mimics peptide bonds to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in asymmetric synthesis to introduce stereocenters with high enantiomeric purity.
• Medicinal Chemistry Research: A valuable tool for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Item	Details
Product Name	1,4-Piperazinedicarboxylic Acid, 2-(Hydroxymethyl)-, 1-(1,1-Dimethylethyl) 4-(Phenylmethyl) Ester, (2S)-
CAS No.	385802-84-6
Molecular Formula	C18H26N2O5
Molecular Weight	350.41 g/mol
Synonyms	(2S)-1-(tert-Butyl) 4-benzyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate; (S)-1-Boc-4-Cbz-2-(hydroxymethyl)piperazine; (S)-1-(tert-Butoxycarbonyl)-4-(benzyloxycarbonyl)-2-(hydroxymethyl)piperazine; (S)-N-Boc-N'-Cbz-2-(hydroxymethyl)piperazine; (2S)-2-(Hydroxymethyl)-1,4-piperazinedicarboxylic Acid 1-(1,1-Dimethylethyl) 4-(Phenylmethyl) Ester; 385802-84-6; (S)-1-Boc-4-Cbz-Pip(2-CH2OH); Chiral Piperazine Derivative
EINECS	Contact for details

Quality Control

Our 1,4-Piperazinedicarboxylic Acid, 2-(Hydroxymethyl)-, 1-(1,1-Dimethylethyl) 4-(Phenylmethyl) Ester, (2S)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity, to ensure it meets the high standards required for pharmaceutical R&D and cGMP (current Good Manufacturing Practice) starting material applications. Comprehensive Certificates of Analysis (COA) with full traceability are provided, confirming identity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.