Description

1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Biotinyl) (Sodium Salt) is a high-purity, synthetic phospholipid derivative covalently linked to biotin. This compound is critical for creating stable, functionalized lipid membranes and vesicles for advanced research and diagnostic applications. It is primarily utilized by scientists and manufacturers in the life sciences, pharmaceutical development, and nanotechnology sectors for targeted drug delivery systems, biosensor development, and cellular biology studies.

Application

• Liposome & Nanoparticle Functionalization: Used to incorporate biotin tags onto liposomal surfaces for streptavidin/avidin-based targeting and conjugation strategies in drug delivery.
• Membrane Protein Studies: Serves as a biotinylated lipid anchor for immobilizing proteins or complexes onto solid supports like sensor chips for surface plasmon resonance (SPR) or blotting assays.
• Diagnostic Assay Development: A key component in constructing lipid bilayers for biosensors and diagnostic platforms that require specific molecular capture.
• Cell Biology & Imaging: Enables the labeling and tracking of cellular membranes or engineered exosomes via fluorescent streptavidin probes.
• Bioconjugation & Affinity Purification: Facilitates the purification or isolation of membrane-associated complexes using streptavidin-coated beads or columns.
• Model Membrane Systems: Incorporated into supported lipid bilayers (SLBs) or giant unilamellar vesicles (GUVs) to study biotin-mediated interactions.

Basic Information

Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Biotinyl) (Sodium Salt)
CAS No.	384835-53-4
Molecular Formula	C89H159N4O11PNa
Molecular Weight	1526.2 g/mol (approx.)
Synonyms	Biotinyl Cap PE; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-(biotinyl); Biotinyl-DOPE; Biotin PE; DOPE-Biotin; Biotinylated DOPE; N-(Biotinoyl)-1,2-dioleoyl-sn-glycero-3-phosphoethanolamine sodium salt; 18:1 Biotinyl Cap PE
EINECS	Contact for details

Quality Control

Our 1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Biotinyl) (Sodium Salt) is manufactured under strict quality systems to ensure batch-to-batch consistency and high performance. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and critical functional parameters. We support research and GMP-grade applications with documentation tailored to your regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. This product is hygroscopic (moisture-sensitive) and easily oxidized; allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in chloroform, methanol, DMSO
Biotin Content	≥ 0.9 mol biotin / mol lipid
Residual Solvents (GC)	Meets ICH guidelines
Phosphorus Assay	Conforms to theoretical value

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.