Description

18:1 Phosphatidylbutanol is a high-purity, synthetic phospholipid derivative, a critical intermediate in biochemical research and pharmaceutical development. This compound is essential for studying intracellular signaling pathways, particularly those involving phospholipase D (PLD) activity. It is primarily utilized by researchers and manufacturers in the life sciences, pharmaceutical, and biotechnology sectors for drug discovery, membrane biology studies, and the formulation of advanced lipid-based delivery systems.

Application

• Biochemical Research: A key substrate and inhibitor for investigating phospholipase D (PLD) enzyme kinetics and signal transduction mechanisms.
• Pharmaceutical Development: Serves as a critical intermediate in the synthesis of novel drug candidates targeting lipid metabolism and cellular signaling.
• Lipidomics & Metabolomics: Used as a standard reference material for the qualitative and quantitative analysis of complex lipid mixtures via LC-MS.
• Membrane Biophysics: Employed in model membrane systems (e.g., liposomes, bilayers) to study membrane fluidity, protein-lipid interactions, and fusion processes.
• Cell Biology: Applied in cellular assays to modulate and trace phosphoinositide pathways and vesicular trafficking.
• Diagnostic Reagent Formulation: A potential component in the development of specialized diagnostic kits and assays.

Basic Information

Product Name	18:1 Phosphatidylbutanol
CAS No.	384835-47-6
Molecular Formula	C44H84NO9P
Molecular Weight	802.10 g/mol
Synonyms	1-Oleoyl-2-hydroxy-sn-glycero-3-phosphobutanol; (18:1) Phosphatidylbutanol; PBut(18:1/0:0); 1-(9Z-Octadecenoyl)-2-hydroxy-sn-glycero-3-phosphobutanol; sn-3-Phosphatidyl-1'-butanol (18:1); PLD substrate 18:1; Lyso-PB(18:1); Phospholipase D Inhibitor/Substrate
EINECS	Contact for details

Quality Control

Our 18:1 Phosphatidylbutanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. The product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95% (Area %)
Assay (HPLC)	≥ 98%
Solubility	Soluble in chloroform, methanol, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.