Description

1,2-Dioleoyl-Sn-Glycero-3-Phosphopropanol (Sodium Salt) is a high-purity, synthetic phospholipid derivative, specifically a phosphatidylpropanolamine, widely used as a critical functional excipient and raw material. Its value lies in its unique amphiphilic structure, which enables the formation of stable lipid bilayers and vesicles, making it indispensable for advanced drug delivery systems. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors, particularly for developing liposomal formulations, lipid nanoparticles (LNPs), and other nanocarriers.

Application

• Lipid Nanoparticle (LNP) Formulation: A key structural lipid component for mRNA, siRNA, and gene therapy delivery systems.
• Liposome Production: Used in the manufacture of stable, uniform liposomes for encapsulating hydrophobic and hydrophilic active pharmaceutical ingredients (APIs).
• Biomimetic Membrane Research: Serves as a model phospholipid for studying membrane fluidity, protein-lipid interactions, and cell membrane mechanics.
• Cosmetic Nanocarriers: Employed in high-end cosmetic formulations for the targeted and sustained delivery of vitamins, antioxidants, and other active compounds.
• Diagnostic Reagents: Utilized in the development of contrast agents and diagnostic kits that require stable lipid-based particles.
• Surface Modification: Acts as a functional coating or linker on surfaces and nanoparticles to improve biocompatibility and specific targeting.

Basic Information

Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phosphopropanol (Sodium Salt)
CAS No.	384835-46-5
Molecular Formula	C42H78NNaO8P
Molecular Weight	778.99 g/mol
Synonyms	DOPP-Na; 1,2-Dioleoyl-sn-glycero-3-phospho-N-propanol (Sodium Salt); (2R)-2,3-Bis[[(Z)-octadec-9-enoyl]oxy]propyl (3-hydroxypropyl) phosphate (Sodium Salt); Sodium 1,2-dioleoyl-sn-glycero-3-phosphopropanol; Phosphatidylpropanolamine, 1,2-dioleoyl, sodium salt; Lipid 18:1 PA-Propanolamine; DOPA-Propanolamine (Na Salt); (R)-1,2-Dioleoyl-3-(3'-phosphono)propyl-rac-glycerol Sodium Salt
EINECS	Contact for details

Quality Control

Our 1,2-Dioleoyl-Sn-Glycero-3-Phosphopropanol (Sodium Salt) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and GMP-grade applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as identity, purity, and critical impurities. We adhere to relevant ICH guidelines and can provide material to meet specific project requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. This material is hygroscopic (moisture-sensitive) and easily oxidized; therefore, vials should be allowed to equilibrate to room temperature before opening to prevent condensation, and any unused material should be promptly returned to the recommended storage conditions.

Specification

Item	Specification
Appearance	White to off-white waxy solid or film
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
1,2-Dioleoyl Isomer Content	≥ 95.0%
Lyso-Impurity (HPLC)	≤ 1.0%
Solvent Residues (GC)	Meets ICH limits
Water Content (KF)	≤ 1.0%
Phase Transition Temperature (DSC)	Approx. -15°C to -10°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.