Description

4-(3-Amino-Propyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a versatile, Boc-protected piperazine derivative that serves as a critical building block in modern organic synthesis. Its bifunctional nature, featuring both a primary amine and a protected secondary amine, makes it an invaluable intermediate for constructing complex molecular architectures with precise control. This compound is primarily sought after by pharmaceutical and agrochemical research and development teams for the synthesis of active pharmaceutical ingredients (APIs), ligands, and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates, particularly in creating piperazine-based scaffolds for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the piperazine moiety contributes to biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for chelating ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Peptidomimetics & Bio-conjugation: The reactive amino groups facilitate its use in constructing peptide analogs and for bio-conjugation chemistry in probe development.
• Polymer Chemistry: Acts as a monomer or cross-linking agent for specialty polymers, including polyamides and polyurethanes with tailored properties.
• Chemical Research & Development: Essential reagent in medicinal chemistry and process chemistry for lead optimization and scale-up studies.

Basic Information

Product Name	4-(3-Amino-Propyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	373608-48-1
Molecular Formula	C12H25N3O2
Molecular Weight	243.35 g/mol
Synonyms	1-Boc-4-(3-aminopropyl)piperazine; tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate; 4-(3-Aminopropyl)piperazine-1-carboxylic acid tert-butyl ester; N-Boc-4-(3-aminopropyl)piperazine; 1-N-Boc-4-(3-aminopropyl)piperazine; Piperazine-1-carboxylic acid, 4-(3-aminopropyl)-, 1,1-dimethylethyl ester; 373608-48-1
EINECS	Contact for details

Quality Control

Our production of 4-(3-Amino-Propyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Quality is verified against comprehensive specifications using advanced analytical techniques including HPLC, GC, and NMR. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent oxidation and absorption of moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.