Description

2-Oxo-Zoniporide Hydrochloride is a high-purity pharmaceutical intermediate and reference standard of significant importance in modern drug discovery and development. This compound is valued for its role as a key precursor in the synthesis of zoniporide, a potent and selective inhibitor of the sodium-hydrogen exchanger isoform-1 (NHE-1). It is primarily required by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and academic institutions engaged in cardiovascular research and the development of novel cardioprotective agents.

Application

• Pharmaceutical Intermediate: Critical precursor in the multi-step synthesis of the active pharmaceutical ingredient (API) Zoniporide.
• Reference Standard: Used for analytical method development, validation, and quality control (QC) testing in API and finished dosage form manufacturing.
• Biochemical Research: Serves as a tool compound in pharmacological studies to investigate NHE-1 inhibition mechanisms and related cardiac ischemia-reperfusion injury pathways.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale production for new chemical entity (NCE) development.
• Impurity Profiling: Used as a specified impurity standard to monitor and control the quality of zoniporide batches during manufacturing.

Basic Information

Product Name	2-Oxo-Zoniporide Hydrochloride
CAS No.	372078-42-7
Molecular Formula	C15H17ClN4O2 • HCl
Molecular Weight	357.24 g/mol
Synonyms	1-(Quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carboxylic Acid Hydrochloride; Zoniporide Oxo Impurity; Zoniporide Related Compound; 5-Cyclopropyl-1-(5-quinolinyl)-1H-pyrazole-4-carboxylic Acid Hydrochloride; 1-(5-Quinolyl)-5-cyclopropyl-1H-pyrazole-4-carboxylic Acid Hydrochloride; CP-597396 Oxo Impurity; NHE-1 Inhibitor Intermediate
EINECS	Contact for details

Quality Control

Our 2-Oxo-Zoniporide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical development. Certificates of Analysis (COA) with full traceability are provided and can be tailored to meet specific pharmacopeial or client specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.