Description

1,2-Bis(Benzyloxycarbonyl)Piperazine-3-Carboxylic Acid is a key, protected piperazine derivative used as a sophisticated building block in advanced organic synthesis. This compound matters because it provides a versatile chiral scaffold for constructing complex molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of active pharmaceutical ingredients (APIs) and other high-value intermediates.

Application

• Pharmaceutical Intermediate: A crucial chiral building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Peptidomimetic Chemistry: Serves as a constrained, protected dipeptide surrogate in the design and synthesis of peptide analogs and mimetics.
• Ligand and Catalyst Development: Used to create chiral ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Agrochemical Synthesis: An intermediate in the development of advanced, chiral agrochemicals such as herbicides and fungicides.
• Academic and Contract Research: Employed in university and CRO laboratories for methodological development in organic synthesis.
• Custom Chemical Synthesis: A starting material for contract manufacturing organizations (CMOs) producing bespoke fine chemicals for clients.

Basic Information

Product Name	1,2-Bis(Benzyloxycarbonyl)Piperazine-3-Carboxylic Acid
CAS No.	370891-25-1
Molecular Formula	C22H24N2O6
Molecular Weight	412.44 g/mol
Synonyms	1,2-Di-Cbz-piperazine-3-carboxylic acid; (3S)-1,2-Bis[(benzyloxy)carbonyl]-1,2-diazinane-3-carboxylic acid; 1,2-Di-Cbz-3-piperazinecarboxylic acid; 1,2-Bis-Cbz-piperazine-3-carboxylic acid; 1,2-Bis(benzyloxycarbonyl)piperazine-3-carboxylic acid; 3-Piperazinecarboxylic acid, 1,2-bis[(phenylmethoxy)carbonyl]-; Z-Z-Pip(3)-OH; (S)-1,2-Bis(benzyloxycarbonyl)piperazine-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1,2-Bis(Benzyloxycarbonyl)Piperazine-3-Carboxylic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, chiral HPLC) are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.