Description

(S,S)-3-Cbz-3,6-Diazabicyclo[3.2.0]Heptane is a high-purity, chiral bicyclic diazepane derivative, serving as a critical advanced pharmaceutical intermediate (API). Its value lies in its rigid, constrained scaffold which is instrumental for modulating the biological activity and pharmacokinetic properties of novel drug candidates. This compound is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the research and synthesis of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral therapeutics.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its constrained bicyclic structure.
• Process Chemistry & Scale-up: Serves as a starting material or intermediate in the development of robust, scalable synthetic routes for clinical trial material and commercial manufacturing.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening (HTS) against various biological targets.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or template in stereoselective synthesis to introduce complex molecular architectures.
• Bioconjugation & Probe Development: The Cbz-protected amine functionality allows for further derivatization, making it useful for creating chemical probes or bioconjugates.

Basic Information

Product Name	(S,S)-3-Cbz-3,6-Diazabicyclo[3.2.0]Heptane
CAS No.	370881-43-9
Molecular Formula	C15H20N2O2
Molecular Weight	260.33 g/mol
Synonyms	(3S,5S)-3-[(Benzyloxy)carbonyl]-3,6-diazabicyclo[3.2.0]heptane; (3S,5S)-3-(Benzyloxycarbonyl)-3,6-diazabicyclo[3.2.0]heptane; (S,S)-3-(Cbz)-3,6-Diazabicyclo[3.2.0]heptane; (S,S)-3-(N-Carbobenzoxy)-3,6-diazabicyclo[3.2.0]heptane; (3S,5S)-3-[(Phenylmethoxy)carbonyl]-3,6-diazabicyclo[3.2.0]heptane; Cbz-Protected (S,S)-3,6-Diazabicyclo[3.2.0]heptane; Bicyclic Diazepane Cbz Derivative
EINECS	Contact for details

Quality Control

Our (S,S)-3-Cbz-3,6-Diazabicyclo[3.2.0]Heptane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay, enantiomeric excess, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.