Description

2-[1-[(2-Fluorophenyl)Methyl]-1H-Pyrazolo[3,4-B]Pyridin-3-Yl]-4,5,6-Pyrimidinetriamine Trihydrochloride is a high-purity, non-nucleoside small molecule building block of significant interest in pharmaceutical research and development. Its complex heterocyclic structure, featuring a pyrazolopyridine core linked to a pyrimidinetriamine, makes it a valuable intermediate for synthesizing novel therapeutic agents. This compound is primarily targeted at research institutions and pharmaceutical companies engaged in the discovery of kinase inhibitors and other targeted therapies.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel drug candidates, particularly in oncology and inflammatory disease research.
• Kinase Inhibitor Research: Used as a core scaffold or precursor in the development of selective kinase inhibitors due to its pyrazolopyridine pharmacophore.
• Biochemical Tool Compound: Employed in high-throughput screening (HTS) assays and target validation studies to explore new biological pathways.
• Medicinal Chemistry: Provides a versatile template for structure-activity relationship (SAR) studies and lead optimization programs.
• Reference Standard: Used as an analytical standard for quality control and method development in API (Active Pharmaceutical Ingredient) manufacturing.
• Preclinical Development: Supplied for use in early-stage in vitro and in vivo pharmacological studies.

Basic Information

Item	Details
Product Name	2-[1-[(2-Fluorophenyl)Methyl]-1H-Pyrazolo[3,4-B]Pyridin-3-Yl]-4,5,6-Pyrimidinetriamine Trihydrochloride
CAS No.	370879-46-2
Molecular Formula	C17H18Cl3FN8
Molecular Weight	471.73 g/mol
Synonyms	2-[1-[(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4,5,6-pyrimidinetriamine trihydrochloride; 2-(1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine trihydrochloride; 370879-46-2; 1-(2-Fluorobenzyl)-3-(4,5,6-triaminopyrimidin-2-yl)-1H-pyrazolo[3,4-b]pyridine trihydrochloride
EINECS	Contact for details

Quality Control

Our 2-[1-[(2-Fluorophenyl)Methyl]-1H-Pyrazolo[3,4-B]Pyridin-3-Yl]-4,5,6-Pyrimidinetriamine Trihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure it meets the stringent requirements for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.