Description

(E)-5-(4-Hydroxybenzylidene)-2-(4-(2-Nitrophenyl)Piperazin-1-Yl)Thiazol-4(5H)-One is a high-purity, synthetic heterocyclic compound featuring a thiazolone core with a piperazine and a hydroxybenzylidene substituent. This specific molecular architecture makes it a valuable pharmacological research intermediate and a key building block in medicinal chemistry. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of potential drug candidates, particularly for central nervous system (CNS) targets.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and library synthesis.
• Biochemical Tool Compound: Employed in in vitro assays to study enzyme inhibition or receptor modulation due to its piperazine and nitroaryl motifs.
• Fine Chemical Synthesis: Acts as a specialized intermediate for producing complex, high-value organic molecules for research purposes.
• Academic Research: Utilized in universities and research institutes for projects in organic synthesis and drug discovery.

Basic Information

Product Name	(E)-5-(4-Hydroxybenzylidene)-2-(4-(2-Nitrophenyl)Piperazin-1-Yl)Thiazol-4(5H)-One
CAS No.	370853-70-6
Molecular Formula	C20H18N4O4S
Molecular Weight	410.45 g/mol
Synonyms	(E)-5-[(4-Hydroxyphenyl)methylene]-2-[4-(2-nitrophenyl)-1-piperazinyl]-4-thiazolidinone; 5-[(4-Hydroxybenzylidene)]-2-[4-(2-nitrophenyl)piperazin-1-yl]-1,3-thiazol-4(5H)-one; (E)-5-(4-Hydroxybenzylidene)-2-[4-(2-nitrophenyl)piperazin-1-yl]-1,3-thiazol-4(5H)-one; 2-[4-(2-Nitrophenyl)piperazin-1-yl]-5-[(E)-4-hydroxybenzylidene]-1,3-thiazol-4(5H)-one; Thiazol-4(5H)-one, 5-[(E)-(4-hydroxyphenyl)methylene]-2-[4-(2-nitrophenyl)-1-piperazinyl]-; 370853-70-6
EINECS	Contact for details

Quality Control

Our (E)-5-(4-Hydroxybenzylidene)-2-(4-(2-Nitrophenyl)Piperazin-1-Yl)Thiazol-4(5H)-One is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS). Certificates of Analysis (COA) detailing batch-specific results are provided to ensure traceability and compliance with your research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and easily oxidized; for long-term storage, consider keeping the primary container under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.