Description

5-(Difluoromethoxy)-2[[(4-Chloro-3-Methoxy-2-Pyridinyl)Methyl]-Thio]-1H-Benzimidazole is a high-purity advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the synthesis of active pharmaceutical ingredients (APIs) targeting specific therapeutic pathways. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development and production of novel drug candidates.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of proprietary active pharmaceutical ingredients (APIs).
• Drug Discovery & Development: Used in medicinal chemistry research for creating and optimizing new chemical entities with potential therapeutic value.
• Contract Manufacturing (CMO/CDMO): Supplied to contract manufacturing organizations for scale-up and commercial production under cGMP conditions.
• Biochemical Research: Serves as a reagent or reference standard in biochemical and pharmacological studies.
• Custom Synthesis: Base material for the custom synthesis of more complex, target-specific molecules for clinical trials.

Basic Information

Item	Details
Product Name	5-(Difluoromethoxy)-2[[(4-Chloro-3-Methoxy-2-Pyridinyl)Methyl]-Thio]-1H-Benzimidazole
CAS No.	368890-20-4
Molecular Formula	C16H13ClF2N3O2S
Molecular Weight	384.81 g/mol
Synonyms	5-(Difluoromethoxy)-2-[[(4-chloro-3-methoxy-2-pyridinyl)methyl]thio]-1H-benzimidazole; 5-(Difluoromethoxy)-2-(((4-chloro-3-methoxypyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole; 368890-20-4; Benzimidazole, 5-(difluoromethoxy)-2-[[(4-chloro-3-methoxy-2-pyridinyl)methyl]thio]-; DFMPT; Contact for additional trade names and abbreviations.
EINECS	Contact for details

Quality Control

Our production of 5-(Difluoromethoxy)-2[[(4-Chloro-3-Methoxy-2-Pyridinyl)Methyl]-Thio]-1H-Benzimidazole adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical pharmaceutical applications. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, generated using validated analytical methods such as HPLC, GC, and NMR. We support development and commercial projects requiring compliance with cGMP, ICH Q7 guidelines, and relevant pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. This product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5% w/w
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.