Description

Methyl 1,4-Di-Boc-Piperazine-2-Acetate CAS NO 368441-99-0 is a high-purity, protected piperazine derivative widely used as a critical building block in advanced organic synthesis. This compound is essential for the efficient and selective construction of complex molecular architectures, particularly in pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing piperazine or morpholine scaffolds.
• Peptidomimetic Synthesis: Used to introduce protected piperazine-2-acetic acid motifs into peptide analogs and peptidomimetics for drug discovery.
• Ligand and Catalyst Development: Serves as a versatile building block for creating novel chelating ligands, organocatalysts, and metal-organic frameworks (MOFs).
• Combinatorial Chemistry: Employed in solid-phase and solution-phase parallel synthesis libraries to generate diverse compound sets for high-throughput screening.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require complex amine functionalities.
• Polymer Modification: Acts as a functional monomer or cross-linking agent for creating specialty polymers with tailored properties.

Basic Information

Product Name	Methyl 1,4-Di-Boc-Piperazine-2-Acetate
CAS No.	368441-99-0
Molecular Formula	C18H32N2O6
Molecular Weight	372.46 g/mol
Synonyms	1,4-Bis(tert-butoxycarbonyl)-2-(methoxycarbonylmethyl)piperazine; Methyl 2-(1,4-Bis(tert-butoxycarbonyl)piperazin-2-yl)acetate; 1,4-Di-Boc-piperazine-2-acetic acid methyl ester; 2-(Methoxycarbonylmethyl)-1,4-dicarboxylic acid bis(1,1-dimethylethyl) ester piperazine; Methyl 1,4-di-tert-butoxycarbonylpiperazine-2-acetate; 1,4-Di-Boc-2-piperazineacetic acid methyl ester; Methyl (1,4-di-Boc-piperazin-2-yl)acetate
EINECS	Contact for details

Quality Control

Our Methyl 1,4-Di-Boc-Piperazine-2-Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to prevent decomposition. Keep the container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.