Description

tert-Butyl 4-Hydroxy-4-(3-Methoxy-3-Oxoprop-1-Ynyl)Piperidine-1-Carboxylate is a high-value, multi-functional piperidine derivative that serves as a critical advanced intermediate in modern organic synthesis. Its unique structure, featuring a protected amine, a hydroxyl group, and an activated alkyne ester, makes it an exceptionally versatile building block for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, where the piperidine scaffold is a common pharmacophore.
• Chemical Biology Probe Development: The alkyne handle allows for efficient conjugation via click chemistry (e.g., CuAAC), making it valuable for creating molecular probes and bioconjugates.
• Material Science Research: Serves as a monomer or precursor for specialty polymers and advanced organic materials with tailored properties.
• Academic & Contract Research: Essential reagent for methodological development in organic synthesis and catalysis studies within university and CRO laboratories.

Basic Information

Product Name	tert-Butyl 4-Hydroxy-4-(3-Methoxy-3-Oxoprop-1-Ynyl)Piperidine-1-Carboxylate
CAS No.	365997-16-6
Molecular Formula	C14H21NO5
Molecular Weight	283.32 g/mol
Synonyms	1-Boc-4-hydroxy-4-(3-methoxy-3-oxo-1-propynyl)piperidine; 1-(tert-Butoxycarbonyl)-4-hydroxy-4-(3-methoxy-3-oxo-1-propynyl)piperidine; 4-Hydroxy-4-(3-methoxy-3-oxoprop-1-yn-1-yl)piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-hydroxy-4-(3-methoxy-3-oxoprop-1-yn-1-yl)piperidine-1-carboxylate; 4-(3-Methoxy-3-oxoprop-1-yn-1-yl)-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester; Boc-4-hydroxy-4-(methoxycarbonylethynyl)piperidine; 365997-16-6
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 4-Hydroxy-4-(3-Methoxy-3-Oxoprop-1-Ynyl)Piperidine-1-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. All materials are fully characterized and undergo rigorous analytical testing, including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.