Description

Doripenem Hydrate is a broad-spectrum carbapenem antibiotic belonging to the β-lactam class. It is valued for its potent activity against a wide range of Gram-positive and Gram-negative bacteria, including many multi-drug resistant strains. This compound is primarily utilized in the research and development of advanced antibacterial agents and serves as a critical active pharmaceutical ingredient (API) for pharmaceutical manufacturing.

Application

• Active Pharmaceutical Ingredient (API) in the formulation of injectable antibacterial drugs.
• Reference standard for analytical method development and validation in quality control laboratories.
• Biochemical research for studying bacterial resistance mechanisms and antibiotic efficacy.
• Intermediate in the synthesis of novel carbapenem derivatives for pharmaceutical research.
• Manufacturing of high-purity drug substances under current Good Manufacturing Practice (cGMP) standards.

Basic Information

Product Name	Doripenem Hydrate
CAS No.	364622-82-2
Molecular Formula	C15H24N4O6S2 • xH2O
Molecular Weight	420.50 g/mol (anhydrous basis)
Synonyms	Doripenem Monohydrate; S-4661; (4R,5S,6S)-3-[[(3S,5S)-5-[(Sulfamoylamino)methyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid Hydrate; Finibax; Doribax
EINECS	Contact for details

Quality Control

Our Doripenem Hydrate is manufactured and tested to meet stringent pharmaceutical-grade standards. Each batch undergoes comprehensive analysis including identification, purity assay, and impurity profiling to ensure compliance with relevant pharmacopeial guidelines. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under conditions that minimize exposure to atmospheric humidity to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	3.0% - 6.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Bacterial Endotoxins	< 0.10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.