Description

(R)-1-(tert-Butoxycarbonyl)-4-Methylpiperazine-2-Carboxylic Acid is a high-purity, chiral piperazine derivative that serves as a critical building block in modern pharmaceutical synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and chiral catalysts. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for advanced R&D and scale-up production.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Peptidomimetic Chemistry: Used to introduce constrained, chiral piperazine scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Asymmetric Catalyst Ligand Precursor: Serves as a starting material for the preparation of chiral ligands used in asymmetric hydrogenation and other catalytic transformations.
• Agrochemical Research: Employed in the development of advanced, enantiomerically pure pesticides and herbicides.
• Custom Synthesis & Contract Manufacturing: A vital component for custom synthesis houses producing bespoke compounds for client projects.
• Academic & Industrial R&D: Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.

Basic Information

Product Name	(R)-1-(tert-Butoxycarbonyl)-4-Methylpiperazine-2-Carboxylic Acid
CAS No.	363192-62-5
Molecular Formula	C11H20N2O4
Molecular Weight	244.29 g/mol
Synonyms	(R)-1-Boc-4-Methylpiperazine-2-carboxylic Acid; (R)-1-(tert-Butoxycarbonyl)-4-methyl-2-piperazinecarboxylic Acid; (R)-4-Methyl-1-((2-methylpropan-2-yl)oxycarbonyl)piperazine-2-carboxylic Acid; (R)-N-Boc-4-methylpiperazine-2-carboxylic Acid; (R)-1-N-Boc-4-methylpiperazine-2-carboxylic Acid; (2R)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-4-methylpiperazine-2-carboxylic Acid; BOC-(R)-4-Methylpiperazine-2-carboxylic Acid
EINECS	Contact for details

Quality Control

Our (R)-1-(tert-Butoxycarbonyl)-4-Methylpiperazine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.