Description

1-tert-Butyl 3-Methyl (3S,4R)-4-Aminopiperidine-1,3-Dicarboxylate is a high-purity, stereochemically defined chiral piperidine derivative, serving as a critical building block in modern pharmaceutical synthesis. Its value lies in providing a pre-functionalized, enantiomerically pure scaffold that accelerates the development of complex bioactive molecules. This advanced intermediate is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and process development of new therapeutic agents, particularly for central nervous system (CNS) and metabolic disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of potent, selective drug candidates targeting various disease pathways.
• Active Pharmaceutical Ingredient (API) Development: Used in the research and scale-up production of novel APIs, especially those requiring a stereochemically defined piperidine core.
• Protease Inhibitor Synthesis: Serves as a precursor in the construction of molecules designed to inhibit specific proteases involved in disease processes.
• Chemical Biology & Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and the creation of focused compound libraries for high-throughput screening.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in asymmetric catalytic reactions to introduce stereogenic centers.
• Process Chemistry Optimization: Provides a consistent, high-quality starting point for developing efficient, scalable manufacturing routes for clinical and commercial drug supplies.

Basic Information

Product Name	1-tert-Butyl 3-Methyl (3S,4R)-4-Aminopiperidine-1,3-Dicarboxylate
CAS No.	362489-61-0
Molecular Formula	C12H22N2O4
Molecular Weight	258.32 g/mol
Synonyms	(3S,4R)-1-(tert-Butoxycarbonyl)-3-(methoxycarbonyl)-4-aminopiperidine; (3S,4R)-4-Amino-1-Boc-3-(methoxycarbonyl)piperidine; 1-Boc-3-methyl (3S,4R)-4-aminopiperidine-1,3-dicarboxylate; tert-Butyl (3S,4R)-4-amino-3-(methoxycarbonyl)piperidine-1-carboxylate; (3S,4R)-1-N-Boc-3-(COOMe)-4-aminopiperidine; (3S,4R)-4-Aminopiperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester; BOC-4-Amino-3S,4R-piperidine-3-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of 1-tert-Butyl 3-Methyl (3S,4R)-4-Aminopiperidine-1,3-Dicarboxylate adheres to stringent quality management systems, ensuring batch-to-batch consistency suitable for demanding pharmaceutical R&D and scale-up. Products undergo rigorous analytical testing, including chiral HPLC to confirm enantiomeric purity and identity verification by spectroscopic methods. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are provided with each shipment to support your regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.