Description

(E)-3-(4-((4-(2-(1,3-Dioxo-1,3,3a,4,7,7a-Hexahydro-2H-4,7-methanoisoindol-2-yl)ethyl)piperazin-1-yl)sulfonyl)phenyl)acrylic acid is a high-purity, advanced pharmaceutical intermediate featuring a complex, multi-functional molecular architecture. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting specific biological pathways. It is essential for research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, where precise chemical structure and reliable supply are paramount.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, especially in medicinal chemistry research.
• Protease Inhibitor Development: The structural motifs suggest potential application in the design and synthesis of protease inhibitor libraries for drug discovery.
• Bioconjugation & Linker Chemistry: The acrylic acid moiety and sulfonamide group make it suitable for use as a linker in antibody-drug conjugates (ADCs) or other bioconjugation strategies.
• Chemical Biology Probes: Used in the development of activity-based probes (ABPs) or photoaffinity labels for studying enzyme function and target engagement.
• High-Throughput Screening (HTS): Serves as a core scaffold for generating diverse compound libraries to screen for new biological activity.
• Academic & Contract Research: Employed in university and CRO (Contract Research Organization) settings for exploratory synthetic chemistry and pharmacology studies.

Basic Information

Product Name	(E)-3-(4-((4-(2-(1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)ethyl)piperazin-1-yl)sulfonyl)phenyl)acrylic acid
CAS No.	361366-50-9
Molecular Formula	C26H29N3O6S
Molecular Weight	511.59 g/mol
Synonyms	2-[4-[(E)-2-Carboxyethenyl]benzenesulfonyl]-1-[2-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)ethyl]piperazine; (E)-3-[4-[[4-[2-(1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-4,7-methano-2H-isoindol-2-yl)ethyl]-1-piperazinyl]sulfonyl]phenyl]-2-propenoic Acid; trans-3-(4-((4-(2-(1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)ethyl)piperazin-1-yl)sulfonyl)phenyl)acrylic Acid; CAS 361366-50-9; 361366-50-9
EINECS	Contact for details

Quality Control

Our (E)-3-(4-((4-(2-(1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)ethyl)piperazin-1-yl)sulfonyl)phenyl)acrylic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if possible to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.