Description

4-Amino-1-n-Alloc-Piperidine is a specialized, high-purity piperidine derivative featuring an Alloc-protected amine group. This compound is a critical building block in modern pharmaceutical synthesis, particularly for the development of active pharmaceutical ingredients (APIs) and complex organic molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for advanced medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, particularly those requiring selective amine protection and deprotection strategies.
• Peptide Chemistry: Used in solid-phase peptide synthesis (SPPS) and the preparation of peptide mimetics where the Alloc (Allyloxycarbonyl) protecting group is required.
• Ligand and Catalyst Development: Serves as a precursor for creating novel ligands and organocatalysts used in asymmetric synthesis.
• Agrochemical Research: Employed in the research and development of new pesticides and herbicides that incorporate functionalized piperidine scaffolds.
• Chemical Biology Probes: Useful for the design and synthesis of molecular probes to study biological systems and enzyme mechanisms.
• Custom Synthesis: A versatile starting material for contract research organizations (CROs) and CDMOs performing bespoke organic synthesis for clients.

Basic Information

Product Name	4-Amino-1-n-Alloc-Piperidine
CAS No.	358969-71-8
Molecular Formula	C9H16N2O2
Molecular Weight	184.24 g/mol
Synonyms	1-(Allyloxycarbonyl)-4-aminopiperidine; 4-Amino-1-(allyloxycarbonyl)piperidine; 1-N-Alloc-4-aminopiperidine; 4-Aminopiperidine-1-carboxylic acid allyl ester; Piperidine, 4-amino-1-[(2-propen-1-yloxy)carbonyl]-; Allyl 4-aminopiperidine-1-carboxylate; 1-Alloc-4-aminopiperidine
EINECS	Contact for details

Quality Control

Our 4-Amino-1-n-Alloc-Piperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.