Description

3,6-Difluoro-Pyrazine-2-Carboxylic Acid Methyl Ester is a high-purity fluorinated pyrazine derivative serving as a critical synthetic intermediate. Its value lies in the strategic incorporation of fluorine atoms and a reactive ester group, enabling precise molecular modifications in advanced chemical synthesis. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoropyrazine core contributes to enhanced biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialty polymers and organic electronic materials.
• Ligand and Catalyst Development: Employed in organometallic chemistry to construct novel nitrogen-containing ligands for catalytic applications.
• Fluorine Chemistry Research: A valuable substrate for studying fluorination reactions and the effects of fluorine substitution on heterocyclic systems.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in bespoke synthesis projects for clients.

Basic Information

Product Name	3,6-Difluoro-Pyrazine-2-Carboxylic Acid Methyl Ester
CAS No.	356783-26-1
Molecular Formula	C7H4F2N2O2
Molecular Weight	186.12 g/mol
Synonyms	Methyl 3,6-difluoropyrazine-2-carboxylate; 3,6-Difluoropyrazine-2-carboxylic acid methyl ester; 2-Pyrazinecarboxylic acid, 3,6-difluoro-, methyl ester; Difluoropyrazine methyl ester; Methyl 3,6-difluoro-2-pyrazinecarboxylate
EINECS	Contact for details

Quality Control

Our 3,6-Difluoro-Pyrazine-2-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) documenting all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation by atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.