Description

4-(tert-Butoxycarbonyl)Piperazine-1-Carboxylic Acid is a high-purity, protected piperazine derivative that serves as a critical building block in advanced organic synthesis. This compound is essential for the efficient and selective introduction of the piperazine moiety, a privileged scaffold in medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical manufacturers for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of complex molecules targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those containing the piperazine pharmacophore.
• Peptide Synthesis: Used as a protected amino acid derivative for the solid-phase and solution-phase synthesis of peptides and peptidomimetics.
• Chemical Biology & Proteomics: Employed in the design and synthesis of chemical probes, linkers, and affinity tags for studying biological systems.
• Agrochemical Research: Serves as a building block for developing new crop protection agents and pesticides.
• Material Science: Can be utilized in the synthesis of functional polymers and specialty chemicals with specific amine-reactive properties.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring high-purity, protected heterocyclic intermediates.

Basic Information

Product Name	4-(tert-Butoxycarbonyl)Piperazine-1-Carboxylic Acid
CAS No.	356517-38-9
Molecular Formula	C10H18N2O4
Molecular Weight	230.26 g/mol
Synonyms	1-Boc-piperazine-4-carboxylic acid; 4-(Boc)piperazine-1-carboxylic acid; 1-N-Boc-piperazine-4-carboxylic acid; Piperazine-1,4-dicarboxylic acid 1-tert-butyl ester; tert-Butyl piperazine-1,4-dicarboxylate; 4-Carboxy-1-piperazinecarboxylic acid tert-butyl ester; Boc-Pip-OH; Boc-Piperazine-4-COOH
EINECS	Contact for details

Quality Control

Our 4-(tert-Butoxycarbonyl)Piperazine-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.