Description

Darapladib is a potent and selective inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2), an enzyme implicated in vascular inflammation and atherosclerosis. This compound is a critical research tool and pharmaceutical intermediate for developing novel cardiovascular therapeutics. It is essential for researchers and pharmaceutical manufacturers focused on inflammatory pathways and cardiovascular disease. Darapladib CAS NO 356057-34-6 is supplied to meet the stringent requirements of preclinical and clinical development programs.

Application

• Pharmaceutical Research & Development: Primary use as a reference standard and active pharmaceutical ingredient (API) in cardiovascular drug discovery programs targeting Lp-PLA2.
• Biochemical Assay Development: Employed as a selective inhibitor to study the role and mechanism of Lp-PLA2 in enzymatic assays and cellular models.
• Preclinical Studies: Utilized in animal models of atherosclerosis, inflammation, and other cardiovascular diseases to evaluate therapeutic efficacy and pharmacokinetics.
• Chemical Synthesis: Serves as a key intermediate for the synthesis of novel analogs and derivatives for structure-activity relationship (SAR) studies.
• Academic Research: Used in university and institutional labs to investigate inflammatory biomarkers and their link to coronary artery disease.

Basic Information

Product Name	Darapladib
CAS No.	356057-34-6
Molecular Formula	C25H26F3N3O4S
Molecular Weight	521.55 g/mol
Synonyms	SB-480848; Darapladib (SB-480848); 1,1-Dimethylethyl (2S,4R)-4-({4-[(2,4-Difluorophenyl)thio]-3-(trifluoromethyl)-1H-pyrazol-1-yl}methyl)-2-({[3,5-bis(trifluoromethyl)phenyl]methyl}amino)carbonyl]-1-pyrrolidinecarboxylate; Lp-PLA2 Inhibitor; SB480848
EINECS	Contact for details

Quality Control

Our Darapladib is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F), in a dry environment. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.