Description

Pyripyropene B is a potent and selective natural product inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), an enzyme critical for cholesterol esterification and absorption. This compound is of significant interest for research into lipid metabolism and the development of novel therapeutic agents. It serves as a valuable biochemical tool for pharmaceutical R&D, particularly for scientists investigating atherosclerosis, metabolic disorders, and related pathways.

Application

• Pharmaceutical Research & Development: A key reference standard and active biochemical probe for studying ACAT inhibition, cholesterol transport, and lipid metabolism in vitro and in vivo.
• Mechanistic Studies: Used to elucidate the role of ACAT enzymes in foam cell formation, a critical process in the development of atherosclerosis.
• Drug Discovery Screening: Serves as a positive control or lead compound in high-throughput screening assays for identifying new ACAT inhibitors with potential therapeutic value.
• Academic Research: Employed in university and institutional labs for fundamental research on cellular cholesterol homeostasis and its dysregulation in disease states.
• Biochemical Reagent: Utilized as a specific enzyme inhibitor to validate experimental models and assay systems related to lipid biology.

Basic Information

Product Name	Pyripyropene B
CAS No.	151519-44-7
Molecular Formula	C₃₂H₃₅NO₁₄
Molecular Weight	657.62 g/mol
Synonyms	Pyripyropene B; 151519-44-7; ACAT Inhibitor Pyripyropene B; (3S,4aR,5R,6S,8aR)-5-[(2S,3S,4S,5S,6R)-4,5-Dihydroxy-6-methyl-3-[(2E,4E,6E)-8-(2-methylpyridin-3-yl)-2,4,6-octatrienoyl]oxyoxan-2-yl]oxy-6-hydroxy-3,4a,8,8-tetramethyl-2,3,4,4a,5,6,7,8a-octahydronaphthalene-1-carboxylic acid; Mer F2; Pyripyropene derivative
EINECS	Contact for details

Quality Control

Our Pyripyropene B is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and other relevant tests. A detailed Certificate of Analysis (COA) documenting identity, purity, and strength is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.