Description

Rvx297 is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) pharmaceutical intermediate. This compound is critical for the research and development of next-generation antiviral therapies, offering a key building block for active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic research institutions focused on virology and drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel non-nucleoside reverse transcriptase inhibitor (NNRTI) drug candidates.
• Antiviral Research: Used in biochemical and virological assays to study mechanisms of action and resistance profiles against retroviruses.
• Drug Discovery & Development: A vital scaffold for medicinal chemistry programs aimed at optimizing potency, selectivity, and pharmacokinetic properties of antiviral agents.
• Reference Standard: Employed as an analytical standard for quality control and method validation in API manufacturing.
• Preclinical Studies: Utilized in *in vitro* and *in vivo* studies to evaluate the efficacy and safety of new therapeutic entities.

Basic Information

Product Name	Rvx297
CAS No.	1044871-04-6
Molecular Formula	C20H21FN6O2
Molecular Weight	396.42 g/mol
Synonyms	4-[[4-[[4-(2-Cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile; Rilpivirine Intermediate; TMC278 Intermediate; 1044871-04-6; Rvx 297; Rvx-297; GSK-297; GSK297
EINECS	Contact for details

Quality Control

Our Rvx297 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.