Description

Balicatib is a potent and selective inhibitor of cathepsin K, a key enzyme involved in bone resorption. This compound is of significant interest for research into metabolic bone diseases such as osteoporosis. It serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate for pharmaceutical development and advanced biochemical studies. Researchers and manufacturers in the pharmaceutical and biotechnology sectors require this high-purity compound for drug discovery and process development.

Application

• Primary pharmaceutical research into osteoporosis and other bone-related disorders.
• Use as a reference standard in analytical method development and validation (HPLC, LC-MS).
• Preclinical and clinical drug development for cathepsin K inhibition.
• Biochemical research to study the mechanism of action of cysteine protease inhibitors.
• Intermediate in the synthesis of novel therapeutic agents targeting bone metabolism.

Basic Information

Product Name	Balicatib
CAS No.	354813-19-7
Molecular Formula	C₁₅H₁₅F₂N₃O₃
Molecular Weight	323.29 g/mol
Synonyms	AAE581; N-((1S)-2,2,2-Trifluoro-1-[4'-fluoro(1,1'-biphenyl)-4-yl]ethyl)-4-fluoro-4-methylpiperidine-1-carboxamide; (S)-N-(2,2,2-Trifluoro-1-(4'-fluoro-[1,1'-biphenyl]-4-yl)ethyl)-4-fluoro-4-methylpiperidine-1-carboxamide; Balicatib (AAE581); Cathepsin K Inhibitor AAE581
EINECS	Contact for details

Quality Control

Our Balicatib is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant ICH guidelines for stability and impurity characterization to support regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.