Description

1-Hexadecyl-2-Azelaoyl-Sn-Glycero-3-Phosphocholine is a synthetic, high-purity phospholipid derivative, specifically a phosphatidylcholine analogue with a defined azelaoyl fatty acid chain. This compound is of significant value for its role as a key intermediate and functional lipid in advanced formulation research. It is primarily needed by researchers and manufacturers in the pharmaceutical and biotechnology sectors for developing novel lipid-based delivery systems, including liposomes and lipid nanoparticles for drug and gene delivery.

Application

• Liposome and Lipid Nanoparticle (LNP) Formulation: A critical building block for constructing stable, targeted drug delivery vehicles for mRNA, siRNA, and small molecule therapeutics.
• Biomembrane Research: Used as a model phospholipid to study membrane fluidity, permeability, and protein-lipid interactions due to its specific acyl chain composition.
• Excipient Development: Serves as a functional excipient in advanced parenteral and topical formulations to enhance solubility and bioavailability of active pharmaceutical ingredients (APIs).
• Diagnostic Reagent Component: Incorporated into reagents and kits used for cell analysis, imaging, and diagnostic assays.
• Cosmetic Actives Carrier: Employed in high-end cosmetic formulations to improve the skin penetration and stability of active compounds.

Basic Information

Product Name	1-Hexadecyl-2-Azelaoyl-Sn-Glycero-3-Phosphocholine
CAS No.	354583-69-0
Molecular Formula	C₃₆H₇₂NO₉P
Molecular Weight	694.0 g/mol (approx.)
Synonyms	PC(16:0-9:0); 1-Palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine; Azelaoylphosphatidylcholine; Phosphatidylcholine (16:0/9:0); 1-Hexadecanoyl-2-nonanediocyl-sn-glycero-3-phosphocholine; (2R)-2,3-Bis(azelaoyloxy)propyl 2-(trimethylammonio)ethyl phosphate (related structure); Synthetic Phospholipid 354583-69-0
EINECS	Contact for details

Quality Control

Our 1-Hexadecyl-2-Azelaoyl-Sn-Glycero-3-Phosphocholine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical development. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.