Description

1-Boc-4-(Cbz-Aminomethylcarbonyl)Piperazine is a high-purity, bifunctional piperazine derivative designed for advanced pharmaceutical synthesis. This compound serves as a critical protected building block, enabling the controlled introduction of amine and carbonyl functionalities in complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and biotechnology industries for the development of novel active pharmaceutical ingredients (APIs) and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Peptidomimetic Chemistry: Used to construct peptide backbones and introduce specific conformational constraints in the design of protease inhibitors and receptor ligands.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Custom Synthesis & Contract Manufacturing: Serves as a specialized starting material for custom synthesis organizations (CSOs) and CDMOs producing gram to kilogram quantities for clinical trial materials.
• Protecting Group Strategy: The tert-butoxycarbonyl (Boc) and carboxybenzyl (Cbz) groups provide orthogonal protection for amines, facilitating sequential deprotection in complex synthetic routes.
• Bioconjugation & Linker Chemistry: Can be utilized to create cleavable linkers in antibody-drug conjugates (ADCs) or other targeted delivery systems.

Basic Information

Product Name	1-Boc-4-(Cbz-Aminomethylcarbonyl)Piperazine
CAS No.	353495-62-2
Molecular Formula	C19H27N3O5
Molecular Weight	377.44 g/mol
Synonyms	1-Boc-4-[(Cbz-amino)acetyl]piperazine; 1-(tert-Butoxycarbonyl)-4-[(benzyloxycarbonylamino)acetyl]piperazine; 4-[(Benzyloxycarbonylamino)acetyl]-1-(tert-butoxycarbonyl)piperazine; N-[(Benzyloxy)carbonyl]glycyl-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 1-Boc-piperazine-4-carboxylic acid, Cbz-Gly amide; tert-Butyl 4-({[(benzyloxy)carbonyl]amino}acetyl)piperazine-1-carboxylate; Boc-Pip(Cbz-Gly)-OH (common abbreviation); 353495-62-2
EINECS	Contact for details

Quality Control

Our 1-Boc-4-(Cbz-Aminomethylcarbonyl)Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.