Description

(R)-2-Carboxymethyl-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity chiral building block and protected amino acid derivative essential for advanced organic synthesis. This compound matters because it provides a stereochemically defined scaffold for constructing complex molecules, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of active pharmaceutical ingredients (APIs) and other biologically active compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel therapeutic agents, including protease inhibitors and other small molecule drugs.
• Peptidomimetics Synthesis: Used to introduce constrained pipecolic acid analogs into peptide backbones to enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Agrochemical Research: Employed in the development of new pesticides and herbicides that require specific stereochemistry for optimal activity.
• Chemical Biology Probes: Utilized to create labeled or modified amino acid derivatives for studying biological pathways and protein function.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects requiring high enantiomeric purity and reliable supply.

Basic Information

Product Name	(R)-2-Carboxymethyl-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	351410-32-7
Molecular Formula	C13H23NO4
Molecular Weight	257.33 g/mol
Synonyms	(R)-1-(tert-Butoxycarbonyl)-2-piperidineacetic Acid; (R)-1-Boc-2-piperidineacetic Acid; (R)-N-Boc-pipecolic Acid-2-Acetic Acid; (R)-2-(Carboxymethyl)piperidine-1-carboxylic Acid tert-Butyl Ester; (R)-1-Boc-pipecolic Acid Acetic Acid Derivative; tert-Butyl (R)-2-(carboxymethyl)piperidine-1-carboxylate; (R)-Boc-Pip(2-CH2COOH)-OH
EINECS	Contact for details

Quality Control

Our (R)-2-Carboxymethyl-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure it meets the stringent requirements for research and cGMP-grade production. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.