Description

1-[(2,2,2-Trichloroethoxy)Carbonyl]-Piperidine-2-Carboxylic Acid is a specialized organic building block featuring a piperidine core protected by a trichloroethoxycarbonyl (Troc) group. This compound is of significant value in synthetic organic chemistry, particularly in the pharmaceutical and agrochemical sectors, where it serves as a key intermediate for the controlled synthesis of complex molecules. Its primary utility lies in the development of active pharmaceutical ingredients (APIs) and fine chemicals, offering chemists a versatile and selectively removable protecting group strategy. This makes it essential for research institutions and manufacturing facilities engaged in advanced peptide mimetics and heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly those containing piperidine scaffolds.
• Peptide Mimetic Synthesis: Used in the construction of peptidomimetics where the Troc-protected carboxylic acid allows for selective deprotection during sequential coupling steps.
• Agrochemical Research: Serves as an advanced intermediate in the development of new crop protection agents and herbicides.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring high-purity, protected amino acid derivatives.
• Academic & Industrial R&D: Used in research laboratories for methodological development in organic synthesis and protecting group chemistry.

Basic Information

Product Name	1-[(2,2,2-Trichloroethoxy)Carbonyl]-Piperidine-2-Carboxylic Acid
CAS No.	347386-19-0
Molecular Formula	C9H12Cl3NO4
Molecular Weight	304.55 g/mol
Synonyms	2-[(2,2,2-Trichloroethoxy)carbonyl]piperidine-2-carboxylic acid; (2S)-1-[(2,2,2-Trichloroethoxy)carbonyl]piperidine-2-carboxylic acid; Troc-Pip-OH; N-Troc-pipecolic acid; 1-Troc-pipecolic acid; Piperidine-2-carboxylic acid, 1-[(2,2,2-trichloroethoxy)carbonyl]-; 347386-19-0
EINECS	Contact for details

Quality Control

Our production of 1-[(2,2,2-Trichloroethoxy)Carbonyl]-Piperidine-2-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support cGMP-compliant manufacturing for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.