Description

1-(4-Nitro-3-Piperidin-1-Yl-Phenyl)-Piperazine is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is critical for the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and oncology drug discovery pipelines. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers requiring a reliable and consistent supply of specialized building blocks.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of new chemical entities (NCEs) for potential drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for targeting various biological pathways.
• CNS Drug Development: Its structural features make it relevant for research into ligands for neurological receptors.
• Oncology Research: Employed in the synthesis of compounds being investigated for anti-cancer properties.
• Chemical Biology: Acts as a scaffold or probe in biochemical assays and target identification studies.
• Custom Synthesis: A starting material for the contract manufacturing of complex, high-value specialty chemicals.

Basic Information

Product Name	1-(4-Nitro-3-Piperidin-1-Yl-Phenyl)-Piperazine
CAS No.	346704-04-9
Molecular Formula	C15H22N4O2
Molecular Weight	290.36 g/mol
Synonyms	1-[4-Nitro-3-(1-piperidinyl)phenyl]piperazine; 1-(4-Nitro-3-piperidin-1-ylphenyl)piperazine; 4-Nitro-3-piperidin-1-ylphenylpiperazine; 346704-04-9; 1-(4-Nitro-3-piperidino-phenyl)piperazine; 3-Piperidin-1-yl-4-nitrophenylpiperazine
EINECS	Contact for details

Quality Control

Our 1-(4-Nitro-3-Piperidin-1-Yl-Phenyl)-Piperazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, consideration should be given to maintaining an inert atmosphere (e.g., under nitrogen or argon) to preserve stability and purity.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.